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Producción académica de de la Universidad Peruana de Ciencias Aplicadas - UPC
viernes, 26 de junio de 2015
miércoles, 24 de junio de 2015
Delivery by caesarean section and risk of childhood obesity: analysis of a Peruvian prospective cohort
Objectives. We aimed to assess if Caesarean section is a risk factor for overnutrition
in early- and late-childhood, and to assess the magnitude of the effect of child- versus
family-related variables in these risk estimates.
Methods. Longitudinal data from Peruvian children from the Young Lives Study
was used. Outcomes assessed were overweight, obesity, overnutrition (overweight
plus obesity), and central obesity (waist circumference) at the age 5 (first follow-up)
and 7 (second follow-up) years. The exposure of interests was delivery by Caesarean
section. Relative risks (RR) and 95% confidence intervals (95% CI) were calculated
using multivariable models adjusted for child-related (e.g., birth weight) and familyrelated
(e.g., maternal nutritional status) variables.
Results. At baseline, mean age was 11.7 (± 3.5) months and 50.1% were boys.
Children born by Caesarean section were 15.6%. The 10.5% of the children were
overweight and 2.4% were obese. For the obesity outcome, data from 6,038 and
9,625 children-years was included from baseline to the first and second follow-up,
respectively. Compared to those who did not experience Caesarean delivery, the risk
of having obesity was higher in the group born by Caesarean: RRs were higher at
early-childhood (first follow-up: 2.25; 95% CI [1.36–3.74]) than later in life (second
follow-up: 1.57; 95% CI [1.02–2.41]). Family-related variables had a greater effect in
attenuating the risk estimates for obesity at the first, than at the second follow-up.
Conclusion. Our results suggest a higher probability of developing obesity, but not
overweight, among children born by Caesarean section delivery. The magnitude of
risk estimates decreased over time, and family-related variables had a stronger effect
on the risk estimates at early-childhood.
Authors: Carrillo Larco, Rodrigo M.; Miranda, J. Jaime; Bernabe Ortiz, Antonio
Source: Peerj
URL: http://hdl.handle.net/10757/558501
Authors: Carrillo Larco, Rodrigo M.; Miranda, J. Jaime; Bernabe Ortiz, Antonio
Source: Peerj
URL: http://hdl.handle.net/10757/558501
Postoperative Complications in Patients with Unrecognized Obesity Hypoventilation Syndrome Undergoing Elective Non-cardiac Surgery
BACKGROUND:
Among patients with obstructive sleep apnea (OSA) a higher number of medical morbidities are known to be associated with those that have obesity hypoventilation syndrome (OHS) compared to OSA alone. OHS can therefore pose a higher risk of postoperative complications after elective non-cardiac surgery (NCS) and is often unrecognized at the time of surgery. The objective of this study was to retrospectively identify patients with OHS and compare their postoperative outcomes with those who have OSA alone.
METHODS:
Patients meeting criteria for OHS were identified within a large cohort of patients with OSA who underwent elective NCS at a major tertiary care center. We identified postoperative outcomes associated with OSA and OHS as well as the clinical determinants of OHS (BMI, AHI). Multivariable logistic or linear regression models were used for dichotomous or continuous outcomes, respectively.
RESULTS:
Patients with hypercapnia from definite or possible OHS, and overlap syndrome are more likely to develop postoperative respiratory failure [OR: 10.9 (95% CI 3.7-32.3), p<0.0001], postoperative heart failure (p<0.0001), prolonged intubation [OR: 5.4 (95% CI 1.9-15.7), p=0.002), postoperative ICU transfer (OR: 3.8 (95% CI 1.7-8.6), p=0.002]; longer ICU (beta coefficient: 0.86; SE: 0.32, p=0.009) and hospital length of stay (beta coefficient: 2.94; SE: 0.87, p=0.0008) when compared to patients with OSA. Among the clinical determinants of OHS, neither BMI nor AHI showed associations with any postoperative outcomes in univariable or multivariable regression.
CONCLUSIONS:
Better emphasis is needed on preoperative recognition of hypercapnia among patients with OSA or overlap syndrome undergoing elective NCS
Authors: Kaw, Roop; Bhateja, Priyanka; Paz y Mar, Hugo; Hernandez, Adrian V.; Ramaswamy, Anuradha; Deshpande, Abhishek; Aboussouan, Loutfi S.
Source: Chest Journal
URL: http://hdl.handle.net/10757/558500
Authors: Kaw, Roop; Bhateja, Priyanka; Paz y Mar, Hugo; Hernandez, Adrian V.; Ramaswamy, Anuradha; Deshpande, Abhishek; Aboussouan, Loutfi S.
Source: Chest Journal
URL: http://hdl.handle.net/10757/558500
Cannabinoids for Medical Use A Systematic Review and Meta-analysis
Importance Cannabis and cannabinoid drugs are widely used to treat disease or alleviate symptoms, but their efficacy for specific indications is not clear.
Objective To conduct a systematic review of the benefits and adverse events (AEs) of cannabinoids.
Data Sources Twenty-eight databases from inception to April 2015.
Study Selection Randomized clinical trials of cannabinoids for the following indications: nausea and vomiting due to chemotherapy, appetite stimulation in HIV/AIDS, chronic pain, spasticity due to multiple sclerosis or paraplegia, depression, anxiety disorder, sleep disorder, psychosis, glaucoma, or Tourette syndrome.
Data Extraction and Synthesis Study quality was assessed using the Cochrane risk of bias tool. All review stages were conducted independently by 2 reviewers. Where possible, data were pooled using random-effects meta-analysis.
Main Outcomes and Measures Patient-relevant/disease-specific outcomes, activities of daily living, quality of life, global impression of change, and AEs.
Results A total of 79 trials (6462 participants) were included; 4 were judged at low risk of bias. Most trials showed improvement in symptoms associated with cannabinoids but these associations did not reach statistical significance in all trials. Compared with placebo, cannabinoids were associated with a greater average number of patients showing a complete nausea and vomiting response (47% vs 20%; odds ratio [OR], 3.82 [95% CI, 1.55-9.42]; 3 trials), reduction in pain (37% vs 31%; OR, 1.41 [95% CI, 0.99-2.00]; 8 trials), a greater average reduction in numerical rating scale pain assessment (on a 0-10-point scale; weighted mean difference [WMD], −0.46 [95% CI, −0.80 to −0.11]; 6 trials), and average reduction in the Ashworth spasticity scale (WMD, −0.36 [95% CI, −0.69 to −0.05]; 7 trials). There was an increased risk of short-term AEs with cannabinoids, including serious AEs. Common AEs included dizziness, dry mouth, nausea, fatigue, somnolence, euphoria, vomiting, disorientation, drowsiness, confusion, loss of balance, and hallucination.
Conclusions and Relevance There was moderate-quality evidence to support the use of cannabinoids for the treatment of chronic pain and spasticity. There was low-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome. Cannabinoids were associated with an increased risk of short-term AEs.
Authors: Whiting, Penny F.; Wolff, Robert F.; Deshpande, Sohan; Di Nisio, Marcello; Duffy, Steven; Hernandez, Adrian V.;Keurentjes, J. Christiaan; Lang, Shona; Misso, Kate; Ryder, Steve; Schmidlkofer, Simone; Westwood, Marie;Kleijnen, Jos
Source: Journal of the American Medical Association
URL: http://hdl.handle.net/10757/558499
Authors: Whiting, Penny F.; Wolff, Robert F.; Deshpande, Sohan; Di Nisio, Marcello; Duffy, Steven; Hernandez, Adrian V.;Keurentjes, J. Christiaan; Lang, Shona; Misso, Kate; Ryder, Steve; Schmidlkofer, Simone; Westwood, Marie;Kleijnen, Jos
Source: Journal of the American Medical Association
URL: http://hdl.handle.net/10757/558499
martes, 23 de junio de 2015
Poor quality of sleep associated with low adherence to highly active antiretroviral therapy in Peruvian patients with HIV/AIDS
This cross-sectional study analyzed the association between poor quality of sleep and adherence to highly active antiretroviral therapy (HAART) in 389 Peruvian patients with HIV/AIDS. Poor quality of sleep was measured with the Pittsburgh Sleep Quality Index (PSQI) and adherence with the CEAT-VIH (Peruvian adaptation). A Poisson generalized linear model with robust standard errors was used to estimate prevalence ratios and 95%CI. A crude model showed that mild, moderate, and severe poor quality of sleep were associated with inadequate treatment adherence. In the adjusted model for variables associated in the bivariate analysis or variables theoretically associated with adherence, only moderate/severe poor quality of sleep remained associated (PR = 1.34, 95%CI: 1.17-1.54; and PR = 1.34, 95%CI: 1.16-1.57, respectively). The study concluded that moderate/severe poor quality of sleep was independently associated with adherence to HAART. Assessing quality of sleep may be helpful in the comprehensive evaluation of HIV patients.
Authors: Tello Velásquez, Jorge Renzo; Díaz Llanes, Bruno Eduardo; Edward Mezones-Holguín; Rodríguez Morales, Alfonso J.; Huamaní, Charles; Hernández, Adrián V.; Arévalo Abanto, Jorge
Source: Cadernos de Saúde Pública
URL: http://hdl.handle.net/10757/558456
Authors: Tello Velásquez, Jorge Renzo; Díaz Llanes, Bruno Eduardo; Edward Mezones-Holguín; Rodríguez Morales, Alfonso J.; Huamaní, Charles; Hernández, Adrián V.; Arévalo Abanto, Jorge
Source: Cadernos de Saúde Pública
URL: http://hdl.handle.net/10757/558456
lunes, 22 de junio de 2015
Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor
A 37-year-old woman with history of Evans Syndrome with poor response to high-dose corticoid treatment presented to the
emergency department with gastrointestinal and vaginal bleeding. The patient was later diagnosed with severe thrombocytopenia
and a stage G1, well-differentiated gastric neuroendocrine tumor, confirmed by a biopsy. A total gastrectomy was performed
to eradicate the tumor. After being treated with a total splenectomy for her Evans Syndrome with no clinical or laboratory
improvement, she began regular treatment with octreotide on the basis of a possible hepatic metastasis. Days after the
initiation of the octreotide, an increase in the platelet count was evidenced by laboratory findings, from 2,000 platelets/mm3 to
109,000 platelets/mm3
. Weeks later, the hepatic metastasis is discarded by a negative octreotide-body scan, and the octreotide
treatment was interrupted. Immediately after the drug interruption, a progressive and evident descent in the platelet count was
evidenced (4000 platelets/mm3
). The present case report highlights the possible association between octreotide treatment and a
severe thrombocytopenia resistant to conventional treatment.
Authors: Chung Delgado, Kocfa; Revilla Montag, Alejandro; Guillén Bravo, Sonia; Ríos Díaz, Hugo; Alva Muñoz, José C.
Source: Case Reports in Hematology
URL: http://hdl.handle.net/10757/314004
Authors: Chung Delgado, Kocfa; Revilla Montag, Alejandro; Guillén Bravo, Sonia; Ríos Díaz, Hugo; Alva Muñoz, José C.
Source: Case Reports in Hematology
URL: http://hdl.handle.net/10757/314004
Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes
Background: Gastroenteritis by rotavirus is responsible for approximately 810 annual deaths/year in children under 5 years in Peru and emerging rotavirus genotypes have led to concerns regarding cross-protection by the vaccines available. Moreover, there are no reports on the molecular-epidemiology of rotavirus diarrhea in Peru
Methodology: A total of 131 stool samples were obtained from children under 5 years old hospitalized from January 2010 to December 2012 in the Hospital Regional de Cajamarca, Peru. ELISA and RT-PCR techniques were performed for rotavirus detection. G and P typing of rotavirus-positive samples were obtained by semi-nested multiplex RT-PCR and sequencing was performed to confirm the PCR results.
Results: Of the 117 samples available, 18.80% (22/117) tested positive for rotavirus by ELISA and 35.90% (42/117) by RT-PCR. Among the G-genotype identified, G9 in 35.71% (15/42) and G12 in 33.33% (14/42) were the most prevalent. With the most common combination being G12/P6 in 23.81% (10/42).
Conclusions: A high prevalence of the G12/P6 genotype was detected. It is know that this genotype is not covered by the current vaccines available. More in depth studies are needed to know the current rotavirus genotypes presents in Peru.
Authors: Weilg Espejo, Pablo; Orellana Peralta, Fiorella; Cornejo Pacheres, Hernán; Del Valle, Luis J.; Cornejo Tapia, Ángela; Bazán Mayra, Jorge; Ruiz, Joaquim; Del Valle Mendoza, Juana
Source: rans R Soc Trop Med Hyg
URL: http://hdl.handle.net/10757/313901
Authors: Weilg Espejo, Pablo; Orellana Peralta, Fiorella; Cornejo Pacheres, Hernán; Del Valle, Luis J.; Cornejo Tapia, Ángela; Bazán Mayra, Jorge; Ruiz, Joaquim; Del Valle Mendoza, Juana
Source: rans R Soc Trop Med Hyg
URL: http://hdl.handle.net/10757/313901
Probiotics for treating persistent diarrhoea in children
Background
Persistent diarrhoea (diarrhoea lasting more than 14 days) accounts for one third of all diarrhoea related deaths in developing countries
in some studies. Probiotics may help treatment.
Objectives
To evaluate probiotics for treating persistent diarrhoea in children.
Search methods
We searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL, MEDLINE, EMBASE, and LILACS. We also
contacted authors of included trials and organizations working in the field, and checked reference lists. The date of the most recent
search was 13 December 2012
Selection criteria
Randomized controlled trials comparing a specified probiotic agent with placebo or no probiotic in children with persistent diarrhoea.
Data collection and analysis
Two review authors assessed the eligibility, risk of bias, extracted and analysed data. Differences were resolved by discussion. Statistical
analysis were performed using the fixed-effect model and the results were expressed as mean difference (MD) for continuous outcomes
with 95% confidence intervals (CI).
Main results
Four trials were included, with a total number of 464 participants; one trial had a low risk of bias. Meta-analysis showed that probiotics
reduced the duration of persistent diarrhoea (mean difference 4.02 days, 95%CI 4.61 to 3.43 days, n = 324, two trials). Stool frequency
was reduced with probiotics in two trials. One trial reported a shorter hospital stay, which was significant, but numbers were small. No
adverse events were reported.
Authors: Bernaola Aponte, Guillermo; Alfonso Bada Mancilla, Carlos; Yhuri Carreazo, Nilton; Rojas Galarza, Raúl Alberto
Source: Cochrane Database of Systematic Reviews
URL: http://hdl.handle.net/10757/313797
Authors: Bernaola Aponte, Guillermo; Alfonso Bada Mancilla, Carlos; Yhuri Carreazo, Nilton; Rojas Galarza, Raúl Alberto
Source: Cochrane Database of Systematic Reviews
URL: http://hdl.handle.net/10757/313797
Factors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Peru
Background: Long-term exposure to anti-tuberculosis medication increases risk of adverse drug reactions and toxicity. The
objective of this investigation was to determine factors associated with anti-tuberculosis adverse drug reactions in Lima,
Peru, with special emphasis on MDR-TB medication, HIV infection, diabetes, age and tobacco use.
Methodology and Results: A case-control study was performed using information from Peruvian TB Programme. A case
was defined as having reported an anti-TB adverse drug reaction during 2005–2010 with appropriate notification on clinical
records. Controls were defined as not having reported a side effect, receiving anti-TB therapy during the same time that the
case had appeared. Crude, and age- and sex-adjusted models were calculated using odds ratios (OR) and 95% confidence
intervals (95%CI). A multivariable model was created to look for independent factors associated with side effect from anti-TB
therapy. A total of 720 patients (144 cases and 576 controls) were analyzed. In our multivariable model, age, especially those
over 40 years (OR = 3.93; 95%CI: 1.65–9.35), overweight/obesity (OR = 2.13; 95%CI: 1.17–3.89), anemia (OR = 2.10; IC95%:
1.13–3.92), MDR-TB medication (OR = 11.1; 95%CI: 6.29–19.6), and smoking (OR = 2.00; 95%CI: 1.03–3.87) were
independently associated with adverse drug reactions.
Conclusions: Old age, anemia, MDR-TB medication, overweight/obesity status, and smoking history are independent risk
factors associated with anti-tuberculosis adverse drug reactions. Patients with these risk factors should be monitored during
the anti-TB therapy. A comprehensive clinical history and additional medical exams, including hematocrit and HIV-ELISA,
might be useful to identify these patients.
Authors: Chung Delgado, Kocfa; Revilla Montag, Alejandro; Guillen Bravo, Sonia; Velez Segovia, Eduardo; Soria Montoya, Andrea; Nuñez Garbin, Alexandra; Silva Caso, Wilmer; Bernabe Ortiz, Antonio
Source:PLoS ONE
URL: http://hdl.handle.net/10757/313811
Authors: Chung Delgado, Kocfa; Revilla Montag, Alejandro; Guillen Bravo, Sonia; Velez Segovia, Eduardo; Soria Montoya, Andrea; Nuñez Garbin, Alexandra; Silva Caso, Wilmer; Bernabe Ortiz, Antonio
Source:PLoS ONE
URL: http://hdl.handle.net/10757/313811
Facebook Use by Peruvian Physicians:Exposing Private Life to Patients
Facebook, a social networking service with over 100 million
unique users, is widely established in many contexts around the
world. A significant number of physicians have opened Facebook
accounts [1, 2] , which is resulting in major ramifications for the
medical profession.
Authors: Pereyra Elías, Reneé; Nizama-Vía, Ayar; Mayta Tristán, Percy
Source: Med Princ Pract
URL: http://hdl.handle.net/10757/313796
Authors: Pereyra Elías, Reneé; Nizama-Vía, Ayar; Mayta Tristán, Percy
Source: Med Princ Pract
URL: http://hdl.handle.net/10757/313796
Does physicians’ right to strike outweigh students’ right to an education? The on-going ethical dilemma in Peru
Although often viewed as an action of last resort,
going on strike remains a legal and often effective
option for physicians seeking labor improvements
and better working conditions. Indeed, in some
countries, there have been reports of strikes by physicians
(1, 2), followed by ensuing discussions of potential ethical
implications (3 5). However, little has been said about the
consequences of such a mass labor stoppage on undergraduate
medical education and those students who
aspire to the profession.
Authors: Carrillo-Larco, Rodrigo M.; Taype-Rondan, Alvaro; Pereyra Elías, Reneé
Source: Med Educ Online
URL: http://hdl.handle.net/10757/313754
Authors: Carrillo-Larco, Rodrigo M.; Taype-Rondan, Alvaro; Pereyra Elías, Reneé
Source: Med Educ Online
URL: http://hdl.handle.net/10757/313754
Patient safety: A component of health policies to be strengthened in Latin America
Editor:
La identificación de eventos adversos es un
componente de alta relevancia en salud. En América
Latina y el Caribe, tal medición no siempre es tenida
en cuenta pese a la considerable frecuencia con que
tales eventos son reportados — esto sin contar la proporción
de casos que no se consignan en los registros.
Se estima que 10 de cada 100 pacientes hospitalizados
han presentado efectos adversos alguna vez durante
la hospitalización y se espera que la tasa aumente a 20
si se duplica el número de días hospitalizados. En el
Estudio Iberoamericano de Efectos Adversos (IBEAS),
el primer trabajo a gran escala en la región sobre incidentes
que causan daño en la asistencia sanitaria, realizado
en 58 hospitales de cinco países, la prevalencia
estimada de efectos adversos fue de 10%, hallándose
además que más de 28% de los efectos adversos desencadenaron
discapacidad y 6%, muerte.
Authors: Mondragón Cardona, Álvaro; Rojas Mirquez, Johana Carolina; Gómez Ossa, Ricardo; Rodríguez Morales, Alfonso J.; Mezones Holguin, Edward
Source: Rev Panam Salud Publica
URL: http://hdl.handle.net/10757/313742
Authors: Mondragón Cardona, Álvaro; Rojas Mirquez, Johana Carolina; Gómez Ossa, Ricardo; Rodríguez Morales, Alfonso J.; Mezones Holguin, Edward
Source: Rev Panam Salud Publica
URL: http://hdl.handle.net/10757/313742
Bad sleeping quality in patients receiving HAART
Sr. Editor:
El manejo de un paciente infectado por el virus de
inmunodefi ciencia humana (VIH) implica un enfoque
multidisciplinario que incluya diversas esferas de la salud
de la persona1
. Sin embargo, en muchas oportunidades la
evaluación se centra en marcadores meramente biológicos
descuidando aspectos de índole psicológico y social que
tendrían importante repercusión en la calidad de vida
de estos pacientes. Dentro de ellos, las alteraciones del
sueño (AS), son un factor a considerar, más aún cuando
han demostrado tener un impacto negativo en la calidad
de vida de las personas2
, asimismo, un incremento de la
probabilidad de desarrollo de diabetes mellitus, enfermedad
cardiovascular y dolencias respiratorias3
.
Authors: Díaz-Llanes, Bruno E.; Tello-Velásquez, Jorge R.; Mezones Holguin, Edward; Arévalo, Jorge; Rodríguez-Morales, Alfonso J.
Source: Revista Chilena Infectolología
URL: http://hdl.handle.net/10757/313753
Authors: Díaz-Llanes, Bruno E.; Tello-Velásquez, Jorge R.; Mezones Holguin, Edward; Arévalo, Jorge; Rodríguez-Morales, Alfonso J.
Source: Revista Chilena Infectolología
URL: http://hdl.handle.net/10757/313753
Medical students at risk: prevalence and incidence of tuberculin skin test conversion
Introduction: One third of the world population is affected by latent tuberculosis, with 9.4 million new cases;
medical students have 2 to 50 times the probability of acquiring the infection. Objectives: Establish the baseline
prevalence of positive tuberculin skin test (TST) at the beginning of medical studies and determine the incidence
and variables associated with TST conversion in medical students. Materials and Methods: Secondary analysis
of a historical cohort (2007-2010) of medical students in a private Peruvian university. The TST conversion was
evaluated. A binomial regression analysis was applied for each associated variable. Results: 707 medical students
were included, of whom 219 (31%) were male. The basal prevalence of reactive TST was 14.4%. Signifi cant
associations were found with the year of university entry of 2007-08 (p = 0.007) and a history of tuberculosis
(p = 0.02). With a total of 822 person-years, the incidence of conversion was 2.92 cases per 100 person-years
(CI95%: 1.96-4.36). The TST conversion was associated with the year of university entry (RR = 2,55; IC95%:
1,06-6,30) and a body mass index ≥ 25 kg/m2 (RR = 0,16; IC95%: 0,01-0,97). No association was detected with
gender, tobacco or alcohol use. Conclusions: There is evidence of a high basal prevalence of latent tuberculosis
infection in medical students. The incidence rate is within expected values and high in comparison with the general
population. People with BMI ≥ 25 kg/m2 have protection against a latent infection. In medical students, more
attention should be paid to biosecurity.; Introducción: Un tercio de la población mundial presenta una infección tuberculosa latente, con 9,4 millones de casos nuevos reportados en el 2009; los estudiantes de medicina tienen de 2 a 50 veces más probabilidad de adquirir la infección.
Authors: Chung Delgado, Kocfa; Guillén Bravo, Sonia; Navarro Huamán, Laura; Quiroz Portella, Rafael; Revilla Montag, Alejandro; Ruíz Alejos, Andrea; Zapata Pachas, Mariana; Bernabe Ortiz, Antonio
Source: Revista Chilena Infectolología
URL: http://hdl.handle.net/10757/313713
Authors: Chung Delgado, Kocfa; Guillén Bravo, Sonia; Navarro Huamán, Laura; Quiroz Portella, Rafael; Revilla Montag, Alejandro; Ruíz Alejos, Andrea; Zapata Pachas, Mariana; Bernabe Ortiz, Antonio
Source: Revista Chilena Infectolología
URL: http://hdl.handle.net/10757/313713
Mucopolysaccharidosis I, Hurler syndrome: A case report
Mucopolysaccharidosis I (MPS I) is a rare, recessively inherited,
lysosomal storage disorder caused by deficiency on the
enzyme α-L-iduronidase. This defect results in accumulation
of heparan and dermatan sulfate in different tissues and organs
due to a deficiency in the catabolism of glycosaminoglycans.
The overall incidence of MPS I is 0.99-1.99/100.000 live
births. There are three clinical presentations: Hurler (severe),
Hurler Scheie (mild) and Scheie (mild). We report the case of
a 10-years-old male patient diagnosed with Hurler syndrome,
the severe presentation, 5 years ago by enzyme α-L-iduronidase
activity measurement in leukocytes; with a history of recurrent
respiratory infections, umbilical hernia, corneal opacity,
coarse facial features, macroglossia, hearing loss, stiffness of
joints, cardiac compromise, claw hands, mental retardation
and stunted growth. After enzyme replacement therapy the
patient has shown improvement of visceral symptoms, but the
neurological damage continuous in progress.
Key words: mucopolysaccharidosis, Hurler syndrome, MPS 1, Hurler,
genetic disorder, enzymatic replacement therapy, ERT
Authors: Amorín, Milagros; Carlina, Andrea; Prötzel, Ana
Source: Sociedad Argentina de Pediatría (SAP)
URL: http://hdl.handle.net/10757/313689
Authors: Amorín, Milagros; Carlina, Andrea; Prötzel, Ana
Source: Sociedad Argentina de Pediatría (SAP)
URL: http://hdl.handle.net/10757/313689
Videogame "Pitanga Town" in the fight against dengue in Costa Rica
Sr. Editor. Una de las prioridades en salud pública a nivel global es el control de las enfermedades transmitidas por vectores, como el dengue, la malaria, la enfermedad de Chagas, la leishmaniasis, la bartonelosis, entre otras. El dengue es una enfermedad viral transmitida por la picadura de las especies del mosquito Aedes, cuya incidencia global se ha incrementado rápidamente en las últimas décadas, estimándose que causa alrededor de 230 millones de infecciones cada año, de los cuales 25 000 son mortales, localizándose principalmente en regiones tropicales y subtropicales (1). La región de las Américas, durante el año 2013, tuvo el mayor reporte histórico de casos, con más de 2,3 millones de casos notificados por los países.
Autores: Zamora, Antón; Galán Rodas, Edén; Ramírez, Eduardo; Rodríguez Morales, Alfonso J.; Mayta Tristán, Percy
Fuente: Revista Peruana de Medicina Experimental y Salud Pública
URL: http://hdl.handle.net/10757/558313
Autores: Zamora, Antón; Galán Rodas, Edén; Ramírez, Eduardo; Rodríguez Morales, Alfonso J.; Mayta Tristán, Percy
Fuente: Revista Peruana de Medicina Experimental y Salud Pública
URL: http://hdl.handle.net/10757/558313
sábado, 20 de junio de 2015
Association between Facebook Dependence and Poor Sleep Quality: A Study in a Sample of Undergraduate Students in Peru
Objectives: Internet can accelerate information exchange. Social networks are the most accessed especially Facebook. This
kind of networks might create dependency with several negative consequences in people’s life. The aim of this study was to
assess potential association between Facebook dependence and poor sleep quality.
Methodology/Principal Findings: A cross sectional study was performed enrolling undergraduate students of the
Universidad Peruana de Ciencias Aplicadas, Lima, Peru. The Internet Addiction Questionnaire, adapted to the Facebook case,
and the Pittsburgh Sleep Quality Index, were used. A global score of 6 or greater was defined as the cutoff to determine
poor sleep quality. Generalized linear model were used to determine prevalence ratios (PR) and 95% confidence intervals
(95%CI). A total of 418 students were analyzed; of them, 322 (77.0%) were women, with a mean age of 20.1 (SD: 2.5) years.
Facebook dependence was found in 8.6% (95% CI: 5.9%–11.3%), whereas poor sleep quality was present in 55.0% (95% CI:
50.2%–59.8%). A significant association between Facebook dependence and poor sleep quality mainly explained by
daytime dysfunction was found (PR = 1.31; IC95%: 1.04–1.67) after adjusting for age, sex and years in the faculty.
Conclusions: There is a relationship between Facebook dependence and poor quality of sleep. More than half of students
reported poor sleep quality. Strategies to moderate the use of this social network and to improve sleep quality in this
population are needed.
Authors: Wolniczak, Isabella; Caceres-Del Aguila, José Alonso; Palma-Ardiles, Gabriela; Arroyo, Karen J.; Solés-Visscher, Rodrigo; Paredes-Yauri, Stephania; Mego-Aquije, Karina; Bernabe Ortiz, Antonio
Source: PLoS ONE
URL: http://hdl.handle.net/10757/313712
Authors: Wolniczak, Isabella; Caceres-Del Aguila, José Alonso; Palma-Ardiles, Gabriela; Arroyo, Karen J.; Solés-Visscher, Rodrigo; Paredes-Yauri, Stephania; Mego-Aquije, Karina; Bernabe Ortiz, Antonio
Source: PLoS ONE
URL: http://hdl.handle.net/10757/313712
Psychiatric symptoms and insulinoma: a case report
Introduction:Insulinomas are pancreatic endocrine
neoplasms with a low incidence between 1-4 cases
per million per year. Case description: A female
49 years-old with neurological and psychiatric
symptoms were treated for two years as a psychiatric
patient. Presented a glucose value, which reflects
hypoglycemia. The patient was operated with
resolution of symptoms. Conclusion: Assess all
patients with psychiatric symptoms and perform a
complete medical history and laboratory findings,
being the most opportune glucose.
Key words: Insulinoma; hypoglycemia; psychiatry.
Palabras clave: Insulinoma; hipoglicemia; psiquiátrico.
Authors: Colán T, Cristina; Gálvez G. , Andrea; Zevallos D., Carolina
Source: REV CHIL NEURO-PSIQUIAT
URL: http://hdl.handle.net/10757/311275
Authors: Colán T, Cristina; Gálvez G. , Andrea; Zevallos D., Carolina
Source: REV CHIL NEURO-PSIQUIAT
URL: http://hdl.handle.net/10757/311275
Contrast profiles of bullying in Peru and Spain
Dear editor:
We read with greatinterestthe article Bullying among schoolchildren:
differences between victims and aggressors, recently published
in Gaceta Sanitaria.1 Motivated by this study, we would like to
share information about the characteristics of victims and aggressors
of bullying in Peru after an extensive literature search about
this underexplored topic in our country and attempt some comparisons
versus Spain as well as some concluding remarks and
recomendations.
Bullying in Peru, as very likely in Spain, is a hidden and yet
latent phenomenon. Moreover, it varies across regions in our country
and profiles might be different than what is found in Spain.
In a study conducted in an urban Lima school in 2007, victims
usually had fewer friends, spent more time alone at recess and
exhibited decreased self-confidence than non-victims.2 Similarly,
another study conducted in in 2009 found that adolescents with
any physical defects are more prone to being bullied, being excluded
by aggressors and experience discriminative behaviors that
cause impaired social image of the victim and generate rivalries
with peers.3
In Peruvian rural areas adolescent victims tend to be
picked on by peers, be very quiet, fearful and considered small and
weak and not to respond to attacks.
Authors: Leiva Montejo, Angela; León Amenero, Gustavo; Lister del Pino, Patricia; Segura, Eddy R
Source: Gaceta Sanit.aria
URL: http://hdl.handle.net/10757/311272
Authors: Leiva Montejo, Angela; León Amenero, Gustavo; Lister del Pino, Patricia; Segura, Eddy R
Source: Gaceta Sanit.aria
URL: http://hdl.handle.net/10757/311272
Public health and primary health care training in medical students: an experience in Peru
Sr. Editor. La formación en salud pública y atención
primaria de la salud (APS) en las universidades del
Perú, es un tema de vital importancia frente al gran
reto del siglo XXI: subsanar las desigualdades en una
generación, y alcanzar la equidad sanitaria (1). Para
afrontar este reto, muchos de los gobiernos de países
desarrollados y en vías de desarrollo han impulsado
reformas en sus sistemas de salud, basados en la
estrategia de atención primaria de la salud. En el
Perú, el modelo integral de salud basado en familia y
comunidad está siendo implementado por el Ministerio
de Salud (MINSA) (2). Para llevar a cabo estas reformas,
es indispensable contar con un número suficiente de
profesionales de la salud formados en los principios y
estrategias de la APS. Surge, entonces, otro gran reto
del siglo XXI: transformar la educación en salud para
que contribuya a reforzar los sistemas de salud (3).
Authors: Champin, Denisse; Risco de Domínguez, Graciela
Source: Rev Peru Med Exp Salud Publica
URL: http://hdl.handle.net/10757/311271
Authors: Champin, Denisse; Risco de Domínguez, Graciela
Source: Rev Peru Med Exp Salud Publica
URL: http://hdl.handle.net/10757/311271
Design and validation of a scale to assess latin american medical students’ perception on the labour of the first level of health care
Objectives. To design and validate a scale to assess Latin American medical students’ perception on first level of health
care (FLHC). Materials and methods. An observational, analytic and multicentre study was carried out in two phases: i) A
self-administered questionnaire regarding perceptions on FLHClabor was designed. ii) This questionnaire was applied to to
medical students from 18 universities of eight Spanish-speaking Latin American countries. An exploratory factor analysis (EFA)
was performed through a principal components analysis with orthogonal varimax rotation. Sample adequacy was evaluated.
Factor extraction was based on Kaiser’s criteria, Cattell’s Scree test and the explained variance (>5%). Internal consistency was
measured with Cronbach’s alpha. Results. 423 students were included in the analysis; 53.4% were from Peruvian universities.
After the EFA, the questionnaire conserved 11 items, which were distributed in three domains, that explaining together 55.47% of
the total variance: i) Perceptions concerning the FLHC physician; ii) Perceptions concerning the FiLC labor and iii) Perceptions
about the economic consequences of working in FLHC. Conclusion. The scale is composed by three domains and can be used
to assess the perceptions of the medical work on first level of health care of Spanish-speaking Latin American medical students.
Authors: Mayta Tristán, Percy; Mezones Holguin, Edward; Pereyra Elías, Reneé; Montenegro Idrogo, Juan J.; R. Mejia, Christian; Dulanto-Pizzorni, Andrés; R. Muñoz, Sergio
Source: Rev Peru Med Exp Salud Publica
URL: http://hdl.handle.net/10757/311258
Authors: Mayta Tristán, Percy; Mezones Holguin, Edward; Pereyra Elías, Reneé; Montenegro Idrogo, Juan J.; R. Mejia, Christian; Dulanto-Pizzorni, Andrés; R. Muñoz, Sergio
Source: Rev Peru Med Exp Salud Publica
URL: http://hdl.handle.net/10757/311258
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