Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru

BACKGROUND: Diarrheagenic Escherichia coli strains are being recognized as important pediatric enteropathogens worldwide. However, it is unclear whether there are differences in age-related susceptibility to specific strains, especially among infants. METHODS: We conducted a passive surveillance cohort study of diarrhea that involved 1034 children aged 2-12 months in Lima, Peru. Control stool samples were collected from randomly selected children without diarrhea. All samples were analyzed for common enteric pathogens and for diarrheagenic E. coli with use of multiplex real-time polymerase chain reaction. RESULTS: The most frequently isolated pathogens in 1065 diarrheal episodes were diarrheagenic E. coli strains (31%), including enteroaggregative (15.1%) and enteropathogenic E. coli (7.6%). Diarrheagenic E. coli, Campylobacter species, and rotavirus were more frequently isolated from infants aged >or=6 months. Among older infants, diffusely adherent E. coli and enterotoxigenic E. coli were more frequently isolated from diarrheal samples than from control samples (P <.05). Children aged >or=6 months who were infected with enterotoxigenic E. coli had a 4.56-fold increased risk of diarrhea (95% confidence interval, 1.20-17.28), compared with younger children. Persistent diarrhea was more common in infants aged <6 months (13.5% vs 3.6%; P <.001). Among children with diarrheagenic E. coli-positive samples, coinfections with other pathogens were more common in children with diarrhea than in control children (40.1% vs 15.6%; P <.001). CONCLUSIONS: Diarrheagenic E. coli strains were more frequently isolated in samples from older infants. In this setting with high frequency of pathogen exposure and high frequency of breastfeeding, we hypothesize that the major age-related differences result from decreased exposure to milk-related protective factors and from increased exposure to contaminated food and water.
Authors: Ochoa, Theresa J.; Ecker, Lucie; Barletta, Francesca; Mispireta, Mónica L.; Gil, Ana I.; Contreras, Carmen; Molina, Margarita;Amemiya, Isabel; Verastegui, Hector; Hall, Eric R.; Cleary, Thomas G.; Lanata, Claudio F.
Source:Clinical Infectious Diseases 
URL: Full text

Se publicó el último nro. de la Revista Médica Herediana (2015)

La Revista Médica Herediana (RMH) es una publicación patrocinada por la Facultad de Medicina Alberto Hurtado de la Universidad Peruana Cayetano Heredia, que publica resultados de investigaciones originales del área biomédica y de Salud Publica realizados a nivel nacional e internacional.

VOL. 26, NÚM. 1 (2015): ENERO - MARZO 2015

Fuente: Universidad Peruana Cayteno Heridia (UPCH)
URL: Texto completo

Se publicó el último número de la Revista Peruana de Biologia (2015)

Es una publicación científica arbitrada producida por el Instituto de Investigaciones de Ciencias Biológicas Antonio Raimondi, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Lima, Perú; publica artículos completos, originales e inéditos en los temas de biodiversidad, biotecnología, ecología, manejo ambiental y biomedicina.

Vol. 22, Núm. 1 (2015)
Fuente: Portal de Revistas de Investigación UNMSM
URL: Texto completo

The hospitalized patient's perception of the nursing attention in a public hospital

Objetivo Determinar y asociar la percepción del paciente hospitalizado respecto a la atención de enfermería con las variables sociodemográficas y estancia hospitalaria en el servicio de medicina de un hospital público. Método Estudio cuantitativo, descriptivo y transversal con 50 pacientes de ambos sexos mayores de 18 años atendidos en un servicio de medicina. Para la recolección de datos se utilizó el cuestionario de perfil social y el cuestionario de percepción del paciente de la atención de enfermería. Resultados Se observó predominio del sexo femenino, edad entre 40 y 49 años, solteros, con secundaria completa y con menos de 5 días de estancia hospitalaria. La atención de enfermería fue categorizada como medianamente favorable. Los componentes Técnico e Interpersonal fueron categorizados como medianamente favorables y el componente Confort desfavorable. Se observó que la mujer percibe mejor la atención de enfermería. Conclusión Los resultados apuntaron la necesidad de un proceso reflexivo por parte del personal de enfermería para mejorar la atención, la percepción del paciente y brindar un cuidado de calidad.; beto fhon@hotmail.com; Objective To determine and associate the perception of the hospitalized patient regarding the nursing attention, using social and demographical variables and hospital stay in the medical service of a public hospital. Method Quantitative, descriptive and transversal study with 50 patients of both sexes over 18 being treated by a medical service. Data were collected through a social profile questionnaire and a patient questionnaire on their perception of nursing attention. Results There was a prevalence of females, aged between 40 and 49 years old, single, with high-school education and admitted to the hospital for less than 5 days. Nursing attention was categorized as broadly favorable. The Technical and Interpersonal components were categorized as fairly favorable, while Comfort was unfavorable. It was observed that women perceive the nursing attention better than men. Conclusion The results pointed towards the need for a reflexive process for the nursing staff to improve attention and the patient's perception of this, as well as to offer better quality care
Authors: Silva Fhon, J.; Ramón Cordova, S.; Vergaray Villanueva, S.; Palacios Fhon, V.; Partezani Rodrigues, R.
Source: Enfermeria Universitaria
URL: http://hdl.handle.net/10757/555880

Association of poor subjective sleep quality with suicidal ideation among pregnant Peruvian women

Objective: To examine the independent and joint relationships of poor subjective sleep quality and antepartum depression with suicidal ideation among pregnant women. Methods: A cross-sectional study was conducted among 641 pregnant women attending prenatal care clinics in Lima, Peru. Antepartumdepression and suicidal ideationwere assessed using the Patient Health Questionnaire-9 scale. Antepartumsubjective sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Logistic regression procedures were performed to estimate odds ratios (aOR) and 95% confidence intervals (95% CI) adjusted for confounders. Results: Overall, the prevalence of suicidal ideation in this cohort was 16.8% and poor subjective sleep qualitywas more common among women endorsing suicidal ideation as compared to their counterpartswho did not (47.2% vs. 24.8%, Pb.001). After adjustment for confounders including maternal depression, poor subjective sleep quality (defined using the recommended criteria of PSQI global score of N5 vs. ≤5) was associated with a 1.7-fold increased odds of suicidal ideation (aOR=1.67; 95% CI 1.02–2.71). When assessed as a continuous variable, each 1-unit increase in the global PSQI score resulted in an 18% increase in odds for suicidal ideation, even after adjusting for depression (aOR=1.18; 95% CI 1.08–1.28). Women with both poor subjective sleep quality and depression had a 3.5-fold increased odds of suicidal ideation (aOR=3.48; 95% CI 1.96–6.18) as compared with those who had neither risk factor. Conclusion: Poor subjective sleep quality was associated with increased odds of suicidal ideation. Replication of these findings may promote investments in studies designed to examine the efficacy of sleep-focused interventions to treat pregnant women with sleep disorders and suicidal ideation.
Authors: Gelaye, Bizu; Barrios, Yasmin V.; Zhong, Qiu-Yue; Rondon, Marta B.; Borba, Christina P.C.; Sánchez, Sixto E.; Henderson, David C.; Williams, Michelle A.
Source: General Hospital Psychiatry
URL: http://hdl.handle.net/10757/555873