Mostrando entradas con la etiqueta Dengue. Mostrar todas las entradas
Mostrando entradas con la etiqueta Dengue. Mostrar todas las entradas

jueves, 12 de mayo de 2022

Detection of SARS-CoV-2 antibodies in febrile patients from an endemic region of dengue and chikungunya in Peru

Open Access / Acceso abierto

URI: http://hdl.handle.net/10757/659814

DOI: 10.1371/journal.pone.0265820

Enlaces adicionales: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0265820

Introduction The rapid expansion of the novel SARS-CoV-2 virus has raised serious public health concerns due to the possibility of misdiagnosis in regions where arboviral diseases are endemic. We performed the first study in northern Peru to describe the detection of SARSCoV-2 IgM antibodies in febrile patients with a suspected diagnosis of dengue and chikungunya fever. Materials and methods A consecutive cross-sectional study was performed in febrile patients attending primary healthcare centers from April 2020 through March 2021. Patients enrolled underwent serum sample collection for the molecular and serological detection of DENV and CHIKV. Also, serological detection of IgM antibodies against SARS-CoV-2 was performed. Results 464 patients were included during the study period, of which (40.51%) were positive for one pathogen, meanwhile (6.90%) presented co-infections between 2 or more pathogens. The majority of patients with monoinfections were positive for SARS-CoV-2 IgM with (73.40%), followed by DENV 18.09% and CHIKV (8.51%). The most frequent co-infection was DENV + SARS-CoV-2 with (65.63%), followed by DENV + CHIKV and DENV + CHIKV + SARSCoV-2, both with (12.50%). The presence of polyarthralgias in hands (43.75%, p<0.01) and feet (31.25%, p = 0.05) were more frequently reported in patients with CHIKV monoinfection. Also, conjunctivitis was more common in patients positive for SARS-CoV-2 IgM (11.45%, p<0.01). The rest of the symptoms were similar among all the study groups. Conclusion SARS-CoV-2 IgM antibodies were frequently detected in acute sera from febrile patients with a clinical suspicion of arboviral disease. The presence of polyarthralgias in hands and feet may be suggestive of CHIKV infection. These results reaffirm the need to consider SARS-CoV-2 infection as a main differential diagnosis of acute febrile illness in arboviruses endemic areas, as well as to consider co-infections between these pathogens. 


Antibodies, Arthralgia, Chikungunya fever, Chikungunya virus, Coinfection, COVID-19, Cross-Sectional studies, Dengue, Fever, Humans, Immunoglobulin M, Peru, SARS-CoV-2, Zika virus infection

jueves, 21 de julio de 2016

Arboviruses emerging in Peru: need for early detection of febrile syndrome during El Niño episodes

Carta al editor / Letter to editor
The presence of El Niño Southern Oscillation (ENSO) implies the presence of fluctuating rains in coastal areas and these changes influence the occurrence of febrile syndromes outbreaks. In Peru, Aedes aegypti is the vector responsible for various viruses such as the dengue, Zika, chikungunya, which is distributed in 18 Peruvian departments. These viruses cause similar clinical characteristics in the host and for this reason rapid, sensitive and specific diagnostic tests are needed so that the patient can receive timely treatment.


EDITORIAL: Elsevier B.V.
FECHA DE PUBLICACIÓN: JUL 2016

CITACIÓN:
Tantaléan-Yépez D, Sánchez-Carbonel J, Ulloa-Urizar G, Aguilar-Luis MA, Espinoza-Morales D, Silva-Caso W, Pons MJ, Valle-Mendoza Jd, Arboviruses emerging in Peru: need for early detection of febrile syndrome during El Niño episodes, Asian Pacific Journal of Tropical Medicine (2016), doi: 10.1016/j.apjtm.2016.06.018.